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Mechanisms of obesity-induced metabolic and vascular dysfunctions
Obesity has reached epidemic proportions and its prevalence is climbing. Obesity is
characterized by hypertrophied adipocytes with a dysregulated adipokine secretion profile …
characterized by hypertrophied adipocytes with a dysregulated adipokine secretion profile …
Metabolic effects of L‐citrulline in type 2 diabetes
The prevalence of type 2 diabetes (T2D) is increasing worldwide. Decreased nitric oxide
(NO) bioavailability is involved in the pathophysiology of T2D and its complications. l …
(NO) bioavailability is involved in the pathophysiology of T2D and its complications. l …
Altered sialin mRNA gene expression in type 2 diabetic male Wistar rats: implications for nitric oxide deficiency
Nitrate therapy has been suggested to boost nitric oxide (NO) levels in type 2 diabetes
(T2D); however, little is known about nitrate transport across the membranes. This study …
(T2D); however, little is known about nitrate transport across the membranes. This study …
Anti-obesity and anti-diabetic effects of L-citrulline are sex-dependent
Aims Anti-diabetic and anti-obesity effects of L-citrulline (Cit) have been reported in male
rats. This study determined sex differences in response to Cit in Wistar rats. Main methods …
rats. This study determined sex differences in response to Cit in Wistar rats. Main methods …
Inorganic nitrate: A potential prebiotic for oral microbiota dysbiosis associated with type 2 diabetes
Oral microbiota dysbiosis, concomitant with decreased abundance of nitrate (NO 3−)-
reducing bacteria, oral net nitrite (NO 2−) production, and reduced nitric oxide (· NO) …
reducing bacteria, oral net nitrite (NO 2−) production, and reduced nitric oxide (· NO) …
Effect of long-term sodium nitrate administration on diabetes-induced anemia and glucose homeostasis in obese type 2 diabetic male rats
Purpose Anemia is common in patients with type 2 diabetes. This aims at determining long-
term effects of nitrate administration on diabetes-induced anemia in obese type 2 diabetic …
term effects of nitrate administration on diabetes-induced anemia in obese type 2 diabetic …
Circulating markers of nitric oxide homeostasis and cardiometabolic diseases: insights from population-based studies
Emerging data suggest that impaired nitric oxide (NO) homeostasis has a key role in
development of cardiometabolic disorders. The association between circulating levels of NO …
development of cardiometabolic disorders. The association between circulating levels of NO …
Sodium nitrate preconditioning prevents progression of the neuropathic pain in streptozotocin-induced diabetes Wistar rats
Purpose The purpose of the study was to evaluate the possible protective effects of low dose
sodium nitrate preconditioning on the peripheral neuropathy in streptozotocin (STZ)-induced …
sodium nitrate preconditioning on the peripheral neuropathy in streptozotocin (STZ)-induced …
Effects of long-term oral nitrate administration on adiposity in normal adult female rats
Introduction Nitric oxide (NO) deficiency is associated with obesity. Nitrate could act as a
substrate for production of NO and is a novel therapeutic agent in obesity. This study aims at …
substrate for production of NO and is a novel therapeutic agent in obesity. This study aims at …
Long-term nitrate administration increases expression of browning genes in epididymal adipose tissue of male type 2 diabetic rats
Expression of browning genes are lower in both humans and animals with type 2 diabetes
(T2D). This study aims at determining effects of long-term nitrate administration on protein …
(T2D). This study aims at determining effects of long-term nitrate administration on protein …