The critical role of angiogenesis in promoting tumor growth and metastasis is strongly
established. However, tumors show considerable variation in angiogenic characteristics and …

Inflammatory bowel disease (IBD) is a heterogeneous state of chronic intestinal
inflammation of unknown cause encompassing Crohn's disease (CD) and ulcerative colitis …

Nasopharyngeal carcinoma (NPC) is an aggressive malignancy with extremely skewed
ethnic and geographic distributions. Increasing evidence indicates that targeting the tumor …

Antibody-drug conjugates (ADCs) have emerged as a revolutionary therapeutic class,
combining the precise targeting ability of monoclonal antibodies with the potent cytotoxic …

Tumor-associated macrophages (TAMs) can have protumor properties, including
suppressing immune responses, promoting vascularization and, consequently, augmenting …

Human adaptive-like natural killer (NK) cells express low levels of FcεRIγ (FcRγ−/low) and
are reported to accumulate during COVID-19 infection; however, the mechanism underlying …

Immune cell dysfunction within the tumor microenvironment (TME) undermines the control of
cancer progression. Established tumors contain phenotypically distinct, tumor-specific …

Colorectal cancer (CRC) is one of the most common cancer worldwide, with a growing
impact on public health and clinical management. Immunotherapy has shown promise in the …

Since the T-box transcription factors (TFs) T-BET and EOMES are necessary for initiation of
NK cell development, their ongoing requirement for mature NK cell homeostasis, function …

Natural Killer (NK) cells are innate lymphocytes playing pivotal roles in host defense and
immune-surveillance. The homeostatic modulation of germ-line encoded/non-rearranged …