Ferroptosis is a form of regulated cell death that is characterized by iron-dependent
oxidative damage and subsequent plasma membrane ruptures and the release of damage …

Reactive oxygen species (ROS) are generated as by-products of cellular metabolism,
primarily in the mitochondria. When cellular production of ROS overwhelms its antioxidant …

Abstract Hypoxia-inducible factor-1 (HIF-1) has a key role in cellular responses to hypoxia,
including the regulation of genes involved in energy metabolism, angiogenesis and …

In vertebrates, transferrin (Tf) safely delivers iron through circulation to cells. Tf-bound iron is
incorporated through Tf receptor (TfR) 1-mediated endocytosis. TfR1 can mediate cellular …

The advent of O2 in the atmosphere was among the first major pollution events occurred on
earth. The reaction between ferrous iron, very abundant in the reductive early atmosphere …

Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays
essential roles in mammalian development, physiology and disease pathogenesis. The HIF …

Increasingly, perturbations in cellular iron and ferritin are emerging as an important element
in the pathogenesis of disease. These changes in ferritin are important not only in the classic …

Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are mammalian proteins that register
cytosolic iron concentrations and post-transcriptionally regulate expression of iron …

The von Hippel-Lindau tumor suppressor protein (pVHL) has emerged as a key factor in
cellular responses to oxygen availability, being required for the oxygen-dependent …

Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …