Kaposi sarcoma (KS) gained public attention as an AIDS-defining malignancy; its
appearance on the skin was a highly stigmatizing sign of HIV infection during the height of …

Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was
identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the …

The life cycle of Kaposi's sarcoma-associated herpesvirus (KSHV) consists of two phases,
latent and lytic. The virus establishes latency as a strategy for avoiding host immune …

Intrinsic and innate immune responses are essential lines of defense in the body's constant
surveillance of pathogens. The discovery of liquid–liquid phase separation (LLPS) as a key …

DNA has been known to be a potent immune stimulus for more than half a century. However,
the underlying molecular mechanisms of DNA-triggered immune response have remained …

Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8
(HHV-8), is etiologically linked to the development of Kaposi's sarcoma, primary effusion …

Epstein-Barr virus (EBV) has developed effective strategies to evade host innate immune
responses. Here we reported on mitigation of type I interferon (IFN) production by EBV …

Chronic hepatitis B virus (HBV) infection is a major cause of chronic liver disease and
cancer worldwide. The mechanisms of viral genome sensing and the evasion of innate …

Epstein–Barr virus (EBV) successfully persists in the vast majority of adults but causes
lymphoid and epithelial malignancies in a small fraction of latently infected individuals …

Despite only comprising half of all known viral species, RNA viruses are disproportionately
responsible for many of the worst epidemics in human history, including outbreaks of …