Background The gut microbiome is composed of bacteria, archaea, viruses, and eukaryotic
organisms that reside in the gastrointestinal (GI) tract. The bacterial component is the largest …

The high morbidity, mortality, and disability rates associated with cerebrovascular disease
(CeVD) pose a severe danger to human health. Gut bacteria significantly affect the onset …

Background Metronidazole has a substantial impact on the gut microbiome. However, the
recovery of the microbiome after discontinuation of administration, and the metabolic …

Postmenopausal osteoporosis is a common bone metabolic disease, and gut microbiota
(GM) imbalance plays an important role in the development of metabolic bone disease …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease accompanied with
severe paralysis or even death, while the pathogenesis of ALS is still unclear and no …

Background and Purpose—Commensal gut bacteria have a profound impact on stroke
pathophysiology. Here, we investigated whether modification of the microbiota influences …

Ischemic stroke (IS) remains a leading cause of death and long-term disability globally.
Several mechanisms including glutamate excitotoxicity, calcium overload …

Neuropsychiatric disorders shorten human life spans through multiple ways and become
major threats to human health. Exercise can regulate the estrogen signaling, which may be …

More than 50 million people have various forms of cognitive impairment basically caused by
neurodegenerative diseases, such as Alzheimer's, Parkinson's, and cerebrovascular …

Studies have shown that gut microbiota metabolites can enter the central nervous system via
the blood-spinal cord barrier and cause neuroinflammation, thus constituting secondary …