Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions

MD Roberts, JJ McCarthy… - Physiological …, 2023 - journals.physiology.org
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Optimizing Resistance Training for Sprint and Endurance Athletes: Balancing Positive and Negative Adaptations

B Van Hooren, P Aagaard, AJ Blazevich - Sports Medicine, 2024 - Springer
Resistance training (RT) triggers diverse morphological and physiological adaptations that
are broadly considered beneficial for performance enhancement as well as injury risk …

Changes in vastus lateralis fibre cross‐sectional area, pennation angle and fascicle length do not predict changes in muscle cross‐sectional area

BA Ruple, PHC Mesquita, JS Godwin… - Experimental …, 2022 - Wiley Online Library
New Findings What is the central question of this study? Do changes in myofibre cross‐
sectional area, pennation angle and fascicle length predict vastus lateralis whole‐muscle …

Comparisons between skeletal muscle imaging techniques and histology in tracking midthigh hypertrophic adaptations following 10 wk of resistance training

BA Ruple, MA Smith, SC Osburn… - Journal of Applied …, 2022 - journals.physiology.org
This study had two aims. Aim1 was to determine the agreement between midthigh vastus
lateralis (VL) cross-sectional area measured by ultrasound (mCSAUS) versus magnetic …

Molecular predictors of resistance training outcomes in young untrained female adults

MA Smith, CL Sexton, KA Smith… - Journal of Applied …, 2023 - journals.physiology.org
We sought to determine if the myofibrillar protein synthetic (MyoPS) response to a naïve
resistance exercise (RE) bout, or chronic changes in satellite cell number and muscle …

Extracellular matrix content and remodeling markers do not differ in college-aged men classified as higher and lower responders to resistance training

JS Godwin, CL Sexton, NJ Kontos… - Journal of Applied …, 2023 - journals.physiology.org
We determined if skeletal muscle extracellular matrix (ECM) content and remodeling
markers adapted with resistance training or were associated with hypertrophic outcomes …

Effects of low-load resistance training with blood flow restriction on muscle fiber myofibrillar and extracellular area

CA Libardi, JS Godwin, TM Reece… - Frontiers in …, 2024 - frontiersin.org
Blood flow restriction applied during low-load resistance training (LL-BFR) induces a similar
increase in the cross-sectional area of muscle fibers (fCSA) compared to traditional high …

Exercise as Mitochondrial Medicine: How Does the Exercise Prescription Affect Mitochondrial Adaptations to Training?

DJ Bishop, MJC Lee, M Picard - Annual Review of Physiology, 2025 - annualreviews.org
Mitochondria are multifaceted organelles with several life-sustaining functions beyond
energy transformation, including cell signaling, calcium homeostasis, hormone synthesis …

Proteolytic markers associated with a gain and loss of leg muscle mass with resistance training followed by high‐intensity interval training

JM Michel, JS Godwin, DL Plotkin… - Experimental …, 2023 - Wiley Online Library
We recently reported that vastus lateralis (VL) cross‐sectional area (CSA) increases after 7
weeks of resistance training (RT, 2 days/week), with declines occurring following 7 weeks of …

Resistance training diminishes mitochondrial adaptations to subsequent endurance training in healthy untrained men

PHC Mesquita, JS Godwin, BA Ruple… - The Journal of …, 2023 - Wiley Online Library
We investigated the effects of performing a period of resistance training (RT) on the
performance and molecular adaptations to a subsequent period of endurance training (ET) …