Gene regulatory networks in disease and ageing
The precise control of gene expression is required for the maintenance of cellular
homeostasis and proper cellular function, and the declining control of gene expression with …
homeostasis and proper cellular function, and the declining control of gene expression with …
[HTML][HTML] Workability of mRNA sequencing for predicting protein abundance
Transcriptomics methods (RNA-Seq, PCR) today are more routine and reproducible than
proteomics methods, ie, both mass spectrometry and immunochemical analysis. For this …
proteomics methods, ie, both mass spectrometry and immunochemical analysis. For this …
[HTML][HTML] Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle
Dissecting the regulatory mechanisms controlling mammalian transcripts from production to
degradation requires quantitative measurements of mRNA flow across the cell. We …
degradation requires quantitative measurements of mRNA flow across the cell. We …
Method of moments framework for differential expression analysis of single-cell RNA sequencing data
Differential expression analysis of single-cell RNA sequencing (scRNA-seq) data is central
for characterizing how experimental factors affect the distribution of gene expression …
for characterizing how experimental factors affect the distribution of gene expression …
Genome-wide inference reveals that feedback regulations constrain promoter-dependent transcriptional burst kinetics
Gene expression in mammalian cells is highly variable and episodic, resulting in a series of
discontinuous bursts of mRNAs. A challenge is to understand how static promoter …
discontinuous bursts of mRNAs. A challenge is to understand how static promoter …
Population Diversity at the Single-Cell Level
Population-scale single-cell genomics is a transformative approach for unraveling the
intricate links between genetic and cellular variation. This approach is facilitated by cutting …
intricate links between genetic and cellular variation. This approach is facilitated by cutting …
A dynamical perspective: moving towards mechanism in single-cell transcriptomics
RJ Maizels - … Transactions of the Royal Society B, 2024 - royalsocietypublishing.org
As the field of single-cell transcriptomics matures, research is shifting focus from
phenomenological descriptions of cellular phenotypes to a mechanistic understanding of the …
phenomenological descriptions of cellular phenotypes to a mechanistic understanding of the …
Dissecting and improving gene regulatory network inference using single-cell transcriptome data
Single-cell transcriptome data has been widely used to reconstruct gene regulatory
networks (GRNs) controlling critical biological processes such as development and …
networks (GRNs) controlling critical biological processes such as development and …
Leveraging prior knowledge to infer gene regulatory networks from single-cell RNA-sequencing data
Many studies have used single-cell RNA sequencing (scRNA-seq) to infer gene regulatory
networks (GRNs), which are crucial for understanding complex cellular regulation. However …
networks (GRNs), which are crucial for understanding complex cellular regulation. However …
Quantifying Landscape‐Flux via Single‐Cell Transcriptomics Uncovers the Underlying Mechanism of Cell Cycle
Recent developments in single‐cell sequencing technology enable the acquisition of entire
transcriptome data. Understanding the underlying mechanism and identifying the driving …
transcriptome data. Understanding the underlying mechanism and identifying the driving …