Chromatin is partitioned on multiple length scales into subcompartments that differ from
each other with respect to their molecular composition and biological function. It is a key …

One of the most amazing findings in molecular biology was the discovery that eukaryotic
genes are discontinuous, with coding DNA being interrupted by stretches of non-coding …

Visualizing the location and dynamics of RNAs in live cells is key to understanding their
function. Here, we identify two endonuclease-deficient, single-component programmable …

Cells are organized on length scales ranging from ångström to micrometres. However, the
mechanisms by which ångström-scale molecular properties are translated to micrometre …

Alternative splicing (AS) of pre-mRNA is utilized by higher eukaryotes to achieve increased
transcriptome and proteomic complexity. The serine/arginine (SR) splicing factors regulate …

The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to
mediate the functions required for cell viability. Specific, context-dependent and tightly …

Nuclear bodies including nucleoli, Cajal bodies, nuclear speckles, Polycomb bodies, and
paraspeckles are membraneless subnuclear organelles. They are present at steady-state …

The cell nucleus is a highly compartmentalized organelle harbouring a variety of dynamic
membraneless nuclear bodies,,,. How these subnuclear domains are established and …

The biogenesis of the many functional compartments contained in the mammalian cell
nucleus is poorly understood. More specifically, little is known regarding the initial …

Cellular pathways are established and maintained by stochastic interactions of highly
mobile molecules. The nucleolus plays a central role in the regulation of these molecular …