The roles of neutrophil-derived myeloperoxidase (MPO) in diseases: the new progress

W Lin, H Chen, X Chen, C Guo - Antioxidants, 2024 - mdpi.com
Myeloperoxidase (MPO) is a heme-containing peroxidase, mainly expressed in neutrophils
and, to a lesser extent, in monocytes. MPO is known to have a broad bactericidal ability via …

Antioxidant properties of anthocyanins and their mechanism of action in atherosclerosis

C Garcia, CN Blesso - Free Radical Biology and Medicine, 2021 - Elsevier
Atherosclerosis develops due to lipid accumulation in the arterial wall and sclerosis as result
of increased hyperlipidemia, oxidative stress, lipid oxidation, and protein oxidation …

[HTML][HTML] Impact of obesity and metabolic syndrome on immunity

CJ Andersen, KE Murphy, ML Fernandez - Advances in Nutrition, 2016 - Elsevier
Obesity is associated with metabolic disturbances that cause tissue stress and dysfunction.
Obese individuals are at a greater risk for chronic disease and often present with clinical …

Obesity-related changes in high-density lipoprotein metabolism and function

JT Stadler, G Marsche - International journal of molecular sciences, 2020 - mdpi.com
In obese individuals, atherogenic dyslipidemia is a very common and important factor in the
increased risk of cardiovascular disease. Adiposity-associated dyslipidemia is characterized …

[HTML][HTML] Antioxidative activity of high-density lipoprotein (HDL): Mechanistic insights into potential clinical benefit

F Brites, M Martin, I Guillas, A Kontush - BBA clinical, 2017 - Elsevier
Uptake of low-density lipoprotein (LDL) particles by macrophages represents a key step in
the development of atherosclerotic plaques, leading to the foam cell formation. Chemical …

Periodontal systemic associations: review of the evidence

GJ Linden, A Lyons… - Journal of periodontology, 2013 - Wiley Online Library
Aim: To critically appraise recent research into associations between periodontal disease
and systemic diseases and conditions specifically respiratory disease, chronic kidney …

Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport

RS Rosenson, HB Brewer Jr, WS Davidson, ZA Fayad… - Circulation, 2012 - ahajournals.org
High-density lipoprotein (HDL) has been proposed to have several antiatherosclerotic
properties, including the ability to mediate macrophage cholesterol efflux, antioxidant …

Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management

MJ Chapman, HN Ginsberg, P Amarenco… - European heart …, 2011 - academic.oup.com
Even at low-density lipoprotein cholesterol (LDL-C) goal, patients with cardiometabolic
abnormalities remain at high risk of cardiovascular events. This paper aims (i) to critically …

HDL-targeted therapies: progress, failures and future

BA Kingwell, MJ Chapman, A Kontush… - Nature reviews Drug …, 2014 - nature.com
Since the discovery in the 1970s that plasma levels of high-density lipoprotein cholesterol
(HDL-C) are inversely associated with cardiovascular outcome, it has been postulated that …

Biological activities of HDL subpopulations and their relevance to cardiovascular disease

L Camont, MJ Chapman, A Kontush - Trends in molecular medicine, 2011 - cell.com
The concept of raising high-density lipoprotein (HDL) has been the focus of increasing
attention as a strategy to reduce cardiovascular disease. HDL particles are, however, highly …