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ADP-ribosylation from molecular mechanisms to therapeutic implications
ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
The expanding universe of PARP1-mediated molecular and therapeutic mechanisms
D Huang, WL Kraus - Molecular cell, 2022 - cell.com
ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …
[HTML][HTML] Molecular mechanisms of parthanatos and its role in diverse diseases
P Huang, G Chen, W **, K Mao, H Wan… - International journal of …, 2022 - mdpi.com
Differential evolution of apoptosis, programmed necrosis, and autophagy, parthanatos is a
form of cell death mediated by poly (ADP-ribose) polymerase 1 (PARP1), which is caused by …
form of cell death mediated by poly (ADP-ribose) polymerase 1 (PARP1), which is caused by …
Inhibitors of PARP: number crunching and structure gazing
Selective inhibitors of PARP1 and PARP2 (PARP1/2) are used to treat cancer patients with
deficiencies in the repair of DNA via homologous recombination. Here we provide a …
deficiencies in the repair of DNA via homologous recombination. Here we provide a …
[HTML][HTML] ADP-ribose contributions to genome stability and PARP enzyme trap** on sites of DNA damage; paradigm shifts for a coming-of-age modification
É Rouleau-Turcotte, JM Pascal - Journal of Biological Chemistry, 2023 - Elsevier
ADP-ribose is a versatile modification that plays a critical role in diverse cellular processes.
The addition of this modification is catalyzed by ADP-ribosyltransferases, among which …
The addition of this modification is catalyzed by ADP-ribosyltransferases, among which …
Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling
In the mammalian DNA damage response, ADP-ribosylation signalling is of crucial
importance to mark sites of DNA damage as well as recruit and regulate repairs factors …
importance to mark sites of DNA damage as well as recruit and regulate repairs factors …
[HTML][HTML] A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells
Summary Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) not only suppress
PARP1 catalytic activity but also prolong its association to damaged chromatin. Here …
PARP1 catalytic activity but also prolong its association to damaged chromatin. Here …
The regulatory landscape of the human HPF1-and ARH3-dependent ADP-ribosylome
Despite the involvement of Poly (ADP-ribose) polymerase-1 (PARP1) in many important
biological pathways, the target residues of PARP1-mediated ADP-ribosylation remain …
biological pathways, the target residues of PARP1-mediated ADP-ribosylation remain …
[HTML][HTML] Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery
PARP1 rapidly detects DNA strand break damage and allosterically signals break detection
to the PARP1 catalytic domain to activate poly (ADP-ribose) production from NAD+. PARP1 …
to the PARP1 catalytic domain to activate poly (ADP-ribose) production from NAD+. PARP1 …
PARP1 proximity proteomics reveals interaction partners at stressed replication forks
PARP1 mediates poly-ADP-ribosylation of proteins on chromatin in response to different
types of DNA lesions. PARP inhibitors are used for the treatment of BRCA1/2-deficient …
types of DNA lesions. PARP inhibitors are used for the treatment of BRCA1/2-deficient …