Immune modulation of learning, memory, neural plasticity and neurogenesis
Over the past two decades it became evident that the immune system plays a central role in
modulating learning, memory and neural plasticity. Under normal quiescent conditions …
modulating learning, memory and neural plasticity. Under normal quiescent conditions …
BDNF and synaptic plasticity, cognitive function, and dysfunction
B Lu, G Nagappan, Y Lu - Neurotrophic factors, 2014 - Springer
Among all neurotrophins, brain-derived neurotrophic factor (BDNF) stands out for its high
level of expression in the brain and its potent effects on synapses. It is now widely accepted …
level of expression in the brain and its potent effects on synapses. It is now widely accepted …
[HTML][HTML] FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
JC Darnell, SJ Van Driesche, C Zhang, KYS Hung… - Cell, 2011 - cell.com
FMRP loss of function causes Fragile X syndrome (FXS) and autistic features. FMRP is a
polyribosome-associated neuronal RNA-binding protein, suggesting that it plays a key role …
polyribosome-associated neuronal RNA-binding protein, suggesting that it plays a key role …
Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration
H Querfurth, HK Lee - Molecular neurodegeneration, 2021 - Springer
Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …
misfolded protein accumulations may be found in the diverse signaling pathways of the …
A brain-specific microRNA regulates dendritic spine development
GM Schratt, F Tuebing, EA Nigh, CG Kane, ME Sabatini… - Nature, 2006 - nature.com
MicroRNAs are small, non-coding RNAs that control the translation of target messenger
RNAs, thereby regulating critical aspects of plant and animal development. In the …
RNAs, thereby regulating critical aspects of plant and animal development. In the …
[BOOK][B] The hippocampus book
P Andersen - 2007 - books.google.com
The hippocampus is one of a group of remarkable structures embedded within the brain's
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …
Engram cells retain memory under retrograde amnesia
Memory consolidation is the process by which a newly formed and unstable memory
transforms into a stable long-term memory. It is unknown whether the process of memory …
transforms into a stable long-term memory. It is unknown whether the process of memory …
Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model
Blast exposure is associated with traumatic brain injury (TBI), neuropsychiatric symptoms,
and long-term cognitive disability. We examined a case series of postmortem brains from US …
and long-term cognitive disability. We examined a case series of postmortem brains from US …
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
In response to nutrients, energy sufficiency, hormones, and mitogenic agents, S6K1
phosphorylates several targets linked to translation. However, the molecular mechanisms …
phosphorylates several targets linked to translation. However, the molecular mechanisms …
BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis
CR Bramham, E Messaoudi - Progress in neurobiology, 2005 - Elsevier
Interest in BDNF as an activity-dependent modulator of neuronal structure and function in
the adult brain has intensified in recent years. Localization of BDNF-TrkB to glutamate …
the adult brain has intensified in recent years. Localization of BDNF-TrkB to glutamate …