Cerebral hypoxia: its role in age-related chronic and acute cognitive dysfunction
B Snyder, SM Simone, T Giovannetti… - Anesthesia & …, 2021 - journals.lww.com
Postoperative cognitive dysfunction (POCD) has been reported with widely varying
frequency but appears to be strongly associated with aging. Outside of the surgical arena …
frequency but appears to be strongly associated with aging. Outside of the surgical arena …
Contributions of aging to cerebral small vessel disease
TM De Silva, FM Faraci - Annual review of physiology, 2020 - annualreviews.org
Cerebral small vessel disease (SVD) is characterized by changes in the pial and
parenchymal microcirculations. SVD produces reductions in cerebral blood flow and …
parenchymal microcirculations. SVD produces reductions in cerebral blood flow and …
Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure
Deterioration of brain capillary flow and architecture is a hallmark of aging and dementia. It
remains unclear how loss of brain pericytes in these conditions contributes to capillary …
remains unclear how loss of brain pericytes in these conditions contributes to capillary …
Reactive astrocytes facilitate vascular repair and remodeling after stroke
Brain injury causes astrocytes to assume a reactive state that is essential for early tissue
protection, but how reactive astrocytes affect later reparative processes is incompletely …
protection, but how reactive astrocytes affect later reparative processes is incompletely …
Network-driven anomalous transport is a fundamental component of brain microvascular dysfunction
F Goirand, T Le Borgne, S Lorthois - Nature communications, 2021 - nature.com
Blood microcirculation supplies neurons with oxygen and nutrients, and contributes to
clearing their neurotoxic waste, through a dense capillary network connected to larger tree …
clearing their neurotoxic waste, through a dense capillary network connected to larger tree …
Aging drives cerebrovascular network remodeling and functional changes in the mouse brain
Aging is frequently associated with compromised cerebrovasculature and pericytes.
However, we do not know how normal aging differentially impacts vascular structure and …
However, we do not know how normal aging differentially impacts vascular structure and …
Oxygen imaging of hypoxic pockets in the mouse cerebral cortex
Consciousness is lost within seconds upon cessation of cerebral blood flow. The brain
cannot store oxygen, and interruption of oxidative phosphorylation is fatal within minutes …
cannot store oxygen, and interruption of oxidative phosphorylation is fatal within minutes …
Dynamic capillary stalls in reperfused ischemic penumbra contribute to injury: a hyperacute role for neutrophils in persistent traffic jams
Ever since the introduction of thrombolysis and the subsequent expansion of endovascular
treatments for acute ischemic stroke, it remains to be identified why the actual outcomes are …
treatments for acute ischemic stroke, it remains to be identified why the actual outcomes are …
3D transcranial ultrasound localization microscopy for discrimination between ischemic and hemorrhagic stroke in early phase
A Chavignon, V Hingot, C Orset, D Vivien… - Scientific Reports, 2022 - nature.com
Early diagnosis is a critical part of the emergency care of cerebral hemorrhages and
ischemia. A rapid and accurate diagnosis of strokes reduces the delays to appropriate …
ischemia. A rapid and accurate diagnosis of strokes reduces the delays to appropriate …
More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction
Our understanding of how capillary blood flow and oxygen distribute across cortical layers to
meet the local metabolic demand is incomplete. We addressed this question by using two …
meet the local metabolic demand is incomplete. We addressed this question by using two …