Polymerization of ethylene oxide, propylene oxide, and other alkylene oxides: synthesis, novel polymer architectures, and bioconjugation

J Herzberger, K Niederer, H Pohlit, J Seiwert… - Chemical …, 2016 - ACS Publications
The review summarizes current trends and developments in the polymerization of alkylene
oxides in the last two decades since 1995, with a particular focus on the most important …

Polymeric mixed micelles as nanomedicines: Achievements and perspectives

M Cagel, FC Tesan, E Bernabeu, MJ Salgueiro… - European Journal of …, 2017 - Elsevier
During the past few decades, polymeric micelles have raised special attention as novel
nano-sized drug delivery systems for optimizing the treatment and diagnosis of numerous …

Poloxamers, poloxamines and polymeric micelles: Definition, structure and therapeutic applications in cancer

M Almeida, M Magalhães, F Veiga… - Journal of Polymer …, 2018 - Springer
Research for new therapies to treat diseases like cancer, it is one of the focus of Health
Sciences. Nowadays, the available therapeutic strategies have in many cases limitations …

Supramolecular cyclodextrin-based drug nanocarriers

SMN Simões, A Rey-Rico, A Concheiro… - Chemical …, 2015 - pubs.rsc.org
Supramolecular systems formed by the binding of several cyclodextrins (CDs) to polymers or
lipids, either via non-covalent or covalent links, open a wide range of possibilities for the …

Polymeric micelles in mucosal drug delivery: Challenges towards clinical translation

A Sosnik, MM Raskin - Biotechnology advances, 2015 - Elsevier
Polymeric micelles are nanostructures formed by the self-aggregation of copolymeric
amphiphiles above the critical micellar concentration. Due to the flexibility to tailor different …

α-Lipoic acid in Soluplus® polymeric nanomicelles for ocular treatment of diabetes-associated corneal diseases

F Alvarez-Rivera, D Fernández-Villanueva… - Journal of …, 2016 - Elsevier
Abstract α-Lipoic acid (ALA) is a powerful antioxidant valuable for prevention and treatment
of ophthalmic complications such as diabetic keratopathy and retinopathy. The aim of this …

Efavirenz-loaded polymeric micelles for pediatric anti-HIV pharmacotherapy with significantly higher oral bioavailability

DA Chiappetta, C Hocht, C Taira, A Sosnik - Nanomedicine, 2010 - Taylor & Francis
Children constitute the most challenging population in anti-HIV/AIDS pharmacotherapy.
Efavirenz (EFV; aqueous solubility 4 µg/ml, bioavailability 40–45%) is a first-line agent in the …

In situ forming hydrogels based on tyramine conjugated 4-Arm-PPO-PEO via enzymatic oxidative reaction

KM Park, YM Shin, YK Joung, H Shin… - …, 2010 - ACS Publications
Over the past decades, hydrogels have been widely studied as biomaterials for various
biomedical applications like implants, drugs and cell delivery carriers because of their high …

[HTML][HTML] PEO-PPO-PEO tri-block copolymers for gene delivery applications in human regenerative medicine—an overview

A Rey-Rico, M Cucchiarini - International journal of molecular sciences, 2018 - mdpi.com
Lineal (poloxamers or Pluronic®) or X-shaped (poloxamines or Tetronic®) amphiphilic tri-
block copolymers of poly (ethylene oxide) and poly (propylene oxide)(PEO-PPO-PEO) have …

PEO-PPO block copolymers for passive micellar targeting and overcoming multidrug resistance in cancer therapy

C Alvarez-Lorenzo, A Sosnik… - Current drug targets, 2011 - ingentaconnect.com
Drug carriers tailored to fit the physicochemical properties of anticancer agents and the
therapeutic peculiarities of tumor management are envisioned for improving the …