This review examines intermittent target search strategies, which combine phases of slow
motion, allowing the searcher to detect the target, and phases of fast motion during which …

A particle's motion in crowded environments often exhibits anomalous diffusion, whose
nature depends on the situation at hand and is formalized within different physical models …

Constitutive heterochromatin is an important component of eukaryotic genomes that has
essential roles in nuclear architecture, DNA repair and genome stability, and silencing of …

Specific labeling of biomolecules with bright fluorophores is the keystone of fluorescence
microscopy. Genetically encoded self-labeling tag proteins can be coupled to synthetic dyes …

The formation of silenced and condensed heterochromatin foci involves enrichment of
heterochromatin protein 1 (HP1). HP1 can bridge chromatin segments and form liquid …

The cytoplasm is the largest part of the cell by volume and hence its rheology sets the rate at
which cellular shape changes can occur. Recent experimental evidence suggests that …

Biomolecular condensates assemble in living cells through phase separation and related
phase transitions. An underappreciated feature of these dynamic molecular assemblies is …

Imaging single fluorescent proteins in living mammalian cells is challenged by out-of-focus
fluorescence excitation. To reduce out-of-focus fluorescence we developed reflected light …

Increased tissue stiffness is a classic characteristic of solid tumors. One of the major
contributing factors is increased density of collagen fibers in the extracellular matrix (ECM) …

Transcription factors (TFs) bind DNA in a sequence-specific manner and thereby serve as
the protein anchors and determinants of 3D genome organization. Conversely, chromatin …