Liver fibrosis is a wound-healing response generated against an insult to the liver that
causes liver injury. It has the potential to progress into cirrhosis, and if not prevented, it may …

There have been considerable recent advances towards a better understanding of the
complex cellular and molecular network underlying liver fibrogenesis. Recent data indicate …

Multiple etiologies of liver disease lead to liver fibrosis through integrated signaling networks
that regulate the deposition of extracellular matrix. This cascade of responses drives the …

Non‐alcoholic fatty liver disease (NAFLD) represents a histological spectrum of liver disease
associated with obesity, diabetes and insulin resistance that extends from isolated steatosis …

Obesity is a major risk factor for metabolic disease, with white adipose tissue (WAT)
inflammation emerging as a key underlying pathology. Alongside its major role in energy …

Nonalcoholic fatty liver disease (NAFLD) affects approximately 30% of adults and 20% of
children in the United States. Nonalcoholic steatohepatitis (NASH) is its most severe …

Liver natural killer and natural killer T cells not only play a critical role in anti–viral and anti–
tumor defenses but also contribute to the pathogenesis of chronic liver diseases. Hepatic …

Fatty liver disease comprises a spectrum ranging from simple steatosis to steatohepatitis
which can progress to liver cirrhosis and hepatocellular cancer. Hepatic lipotoxicity may …

Since the first mention of fetal programming of adult health and disease, a plethora of
programming events in early life has been suggested. These have included intrauterine and …

Dietary factors promote obesity and obesity‐related disorders, such as fatty liver disease.
Natural killer T (NKT) cells are components of the innate immune system that regulate …