Determining the causes of schizophrenia has been a notoriously intractable problem,
resistant to a multitude of investigative approaches over centuries. In recent decades …

A growing community is constructing a next-generation file format (NGFF) for bioimaging to
overcome problems of scalability and heterogeneity. Organized by the Open Microscopy …

Digital reconstruction of the intricate 3D morphology of individual neurons from microscopic
images is a crucial challenge in both individual laboratories and large-scale projects …

Abstract 3D brain atlases are key resources to understand the brain's spatial organization
and promote interoperability across different studies. However, unlike the adult mouse brain …

Hippocampome. org is a mature open-access knowledge base of the rodent hippocampal
formation focusing on neuron types and their properties. Previously, Hippocampome. org v1 …

Drug discovery is a generally inefficient and capital-intensive process. For
neurodegenerative diseases (NDDs), the development of novel therapeutics is particularly …

Left-right asymmetry of the human brain is widespread through its anatomy and function.
However, limited microscopic understanding of it exists, particularly for anatomical …

Digital reconstructions provide an accurate and reliable way to store, share, model, quantify,
and analyze neural morphology. Continuous advances in cellular labeling, tissue …

We conducted a large-scale whole-brain morphometry study by analyzing 3.7 peta-voxels of
mouse brain images at the single-cell resolution, producing one of the largest multi …

Brain atlases are widely used in neuroscience as resources for conducting experimental
studies, and for integrating, analyzing, and reporting data from animal models. A variety of …