Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a
promising approach for cancer treatment in recent years due to the critical roles of the TME …

Ferroptosis, an iron-dependent programmed cell death mechanism, is regulated by distinct
molecular pathways of lipid peroxidation caused by intracellular iron supplementation and …

Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also
in the activation, differentiation and effector function (s) of immune cells. In this review, we …

The chemokine ligand CCL2 and its receptor CCR2 are implicated in the initiation and
progression of various cancers. CCL2 can activate tumour cell growth and proliferation …

Chronic inflammation generated by the tumor microenvironment is known to drive cancer
initiation, proliferation, progression, metastasis, and therapeutic resistance. The tumor …

Summary RNA N 6-methyladenosine (m 6 A) modification is implicated in cancer
progression. However, the impact of m 6 A on the antitumor effects of radiotherapy and the …

Immune evasion and altered metabolism, where glucose utilization is diverted to increased
lactic acid production, are two fundamental hallmarks of cancer. Although lactic acid has …

Suppression of antitumor immune responses is one of the main mechanisms by which tumor
cells escape from destruction by the immune system. Myeloid-derived suppressor cells …

Advances in immunotherapy have led to durable and long‐term benefits in a subset of
patients across a number of solid tumor types. Understanding of the subsets of patients that …

Breast cancer progression is a complex process controlled by genetic and epigenetic factors
that coordinate the crosstalk between tumor cells and the components of tumor …