The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …

Regulated cell death (RCD) relies on activation and recruitment of pore-forming proteins
(PFPs) that function as executioners of specific cell death pathways: apoptosis regulator …

Gasdermin D (GSDMD)-activated inflammatory cell death (pyroptosis) causes mitochondrial
damage, but its underlying mechanism and functional consequences are largely unknown …

Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …

Mitochondria are traditionally known as the powerhouse of the cell, but their functions
extend far beyond energy production. They are vital in cellular and organismal pathways …

For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

We are now near the top of the mitochondrial pathway of apoptosis, at the point before the
mitochondrial outer membrane permeabilizes to release proteins such as cytochrome c into …

Innate immunity is the first response to protect against pathogens and cellular insults.
Pattern recognition receptors sense pathogen-and damage-associated molecular patterns …

The BCl-2 family has long been identified for its role in apoptosis. Following the initial
discovery of BCL-2 in the context of B-cell lymphoma in the 1980s, a number of homologous …

The BCL-2 family of proteins controls cell death primarily by direct binding interactions that
regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible …