WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

During mouse embryonic development a mass of pluripotent epiblast tissue is transformed
during gastrulation to generate the three definitive germ layers: endoderm, mesoderm, and …

Organoid models of early tissue development have been produced for the intestine, brain,
kidney and other organs, but similar approaches for the heart have been lacking. Here we …

Efficient differentiation of embryonic stem cells (ESCs) and induced pluripotent stem cells
(iPSCs) to a variety of lineages requires step-wise approaches replicating the key …

The Wnt signalling pathway is an ancient system that has been highly conserved during
evolution. It has a crucial role in the embryonic development of all animal species, in the …

Abstract Purpose of Review Cardiovascular diseases are the leading cause of death
worldwide, largely due to the limited regenerative capacity of the adult human heart. In …

The cardiomyocyte (CM) subtypes in the mammalian heart derive from distinct lineages
known as the first heart field (FHF), the anterior second heart field (aSHF), and the posterior …

Bone morphogenetic proteins (BMPs) and their receptors, known to be essential regulators
of embryonic patterning and organogenesis, are also critical for the regulation of …

Understanding heart development on a molecular level is a prerequisite for uncovering the
causes of congenital heart diseases. Therapeutic approaches that try to enhance cardiac …

The mammalian heart is the first functional organ, the first indicator of life. Its normal
formation and function are essential for fetal life. Defects in heart formation lead to …