X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

To achieve a balanced gene expression dosage between males (XY) and females (XX),
mammals have evolved a compensatory mechanism to randomly inactivate one of the …

In mammals, the process of X-chromosome inactivation ensures equivalent levels of X-
linked gene expression between males and females through the silencing of one of the two …

A subset of X-linked genes escapes silencing by X inactivation and is expressed from both X
chromosomes in mammalian females. Species-specific differences in the identity of these …

As a result of sex chromosome differentiation from ancestral autosomes, male mammalian
cells only contain one X chromosome. It has long been hypothesized that X-linked gene …

How and why female somatic X-chromosome inactivation (XCI) evolved in mammals
remains poorly understood. It has been proposed that XCI is a dosage-compensation …

Genome stability is a crucial feature of eukaryotic organisms because its alteration
drastically affects the normal development and survival of cells and the organism as a …

Silene latifolia is a dioecious plant with heteromorphic sex chromosomes that have
originated only∼ 10 million years ago and is a promising model organism to study sex …

In female (XX) mammals, one of the two X chromosomes is inactivated to ensure an equal
dose of X-linked genes with males (XY). X-chromosome inactivation in eutherian mammals …

Over the last few decades, an increasing number of vertebrate taxa have been identified that
undergo programmed genome rearrangement, or programmed DNA loss, during …