Progresses in predicting post-translational modification

KC Chou - International Journal of Peptide Research and …, 2020 - Springer
Identification of the sites of post-translational modifications (PTMs) in protein, RNA, and DNA
sequences is currently a very hot topic. This is because the information thus obtained is very …

Proposing pseudo amino acid components is an important milestone for proteome and genome analyses

KC Chou - International Journal of Peptide Research and …, 2020 - Springer
In this minireview paper it has been elucidated that the proposal of pseudo amino acid
components represents a very important milestone for the disciplines of proteome and …

Prediction of citrullination sites by incorporating k-spaced amino acid pairs into Chou's general pseudo amino acid composition

Z Ju, SY Wang - Gene, 2018 - Elsevier
As one of the most important and common protein post-translational modifications,
citrullination plays a key role in regulating various biological processes and is associated …

Predicting lysine phosphoglycerylation with fuzzy SVM by incorporating k-spaced amino acid pairs into Chou׳ s general PseAAC

Z Ju, JZ Cao, H Gu - Journal of Theoretical Biology, 2016 - Elsevier
As a new type of post-translational modification, lysine phosphoglycerylation plays a key
role in regulating glycolytic process and metabolism in cells. Due to the traditional …

Prediction of lysine crotonylation sites by incorporating the composition of k-spaced amino acid pairs into Chou's general PseAAC

Z Ju, JJ He - Journal of Molecular Graphics and Modelling, 2017 - Elsevier
As one of the most important and common histones post-translational modifications,
crotonylation plays a key role in regulating various biological processes. The accurate …

iRSpot-SPI: Deep learning-based recombination spots prediction by incorporating secondary sequence information coupled with physio-chemical properties via …

ZU Khan, F Ali, IA Khan, Y Hussain, D Pi - Chemometrics and Intelligent …, 2019 - Elsevier
Meiotic recombination plays an important role in the process of genetic diversity
generation.“Hotspots” are regions that show a higher rate of meiotic recombination, while …

Prediction of lysine propionylation sites using biased SVM and incorporating four different sequence features into Chou's PseAAC

Z Ju, JJ He - Journal of Molecular Graphics and Modelling, 2017 - Elsevier
Lysine propionylation is an important and common protein acylation modification in both
prokaryotes and eukaryotes. To better understand the molecular mechanism of …

Feature extractions for computationally predicting protein post-translational modifications

G Huang, J Li - Current Bioinformatics, 2018 - ingentaconnect.com
Background: Post-translational modifications (PTMs) are a key regulating mechanism in the
cellular process. It is of importance to quickly and accurately identify PTMs. Both next …

Predicting pupylation sites in prokaryotic proteins using semi-supervised self-training support vector machine algorithm

Z Ju, H Gu - Analytical biochemistry, 2016 - Elsevier
As one important post-translational modification of prokaryotic proteins, pupylation plays a
key role in regulating various biological processes. The accurate identification of pupylation …

predML-site: predicting multiple lysine PTM sites with optimal feature representation and data imbalance minimization

S Ahmed, A Rahman, MAM Hasan… - IEEE/ACM …, 2021 - ieeexplore.ieee.org
Identifying of post-translational modifications (PTM) is crucial in the study of computational
proteomics, cell biology, pathogenesis, and drug development due to its role in many bio …