Screening out irrelevant cell-based models of disease
The common and persistent failures to translate promising preclinical drug candidates into
clinical success highlight the limited effectiveness of disease models currently used in drug …
clinical success highlight the limited effectiveness of disease models currently used in drug …
Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting
C Malainou, SM Abdin, N Lachmann… - The Journal of …, 2023 - Am Soc Clin Investig
Alveolar macrophages (AMs) are the sentinel cells of the alveolar space, maintaining
homeostasis, fending off pathogens, and controlling lung inflammation. During acute lung …
homeostasis, fending off pathogens, and controlling lung inflammation. During acute lung …
Bestrophin 1 and retinal disease
Mutations in the gene BEST1 are causally associated with as many as five clinically distinct
retinal degenerative diseases, which are collectively referred to as the “bestrophinopathies” …
retinal degenerative diseases, which are collectively referred to as the “bestrophinopathies” …
Pluripotent stem cell-derived cerebral organoids reveal human oligodendrogenesis with dorsal and ventral origins
The process of oligodendrogenesis has been relatively well delineated in the rodent brain.
However, it remains unknown whether analogous developmental processes are manifested …
However, it remains unknown whether analogous developmental processes are manifested …
Good cell culture practice for stem cells and stem-cell-derived models
The first guidance on Good Cell Culture Practice dates back to 2005. This document
expands this to aspects of quality assurance for in vitro cell culture focusing on the …
expands this to aspects of quality assurance for in vitro cell culture focusing on the …
[HTML][HTML] Efficient in vivo liver-directed gene editing using CRISPR/Cas9
In vivo tissue-specific genome editing at the desired loci is still a challenge. Here, we report
that AAV9-delivery of truncated guide RNAs (gRNAs) and Cas9 under the control of a …
that AAV9-delivery of truncated guide RNAs (gRNAs) and Cas9 under the control of a …
[HTML][HTML] Clinical aspects of neurointestinal disease: Pathophysiology, diagnosis, and treatment
The enteric nervous system (ENS) is involved in the regulation of virtually all gut functions.
Conditions referred to as enteric neuropathies are the result of various mechanisms …
Conditions referred to as enteric neuropathies are the result of various mechanisms …
Generation and application of novel hES cell reporter lines for the differentiation and maturation of hPS cell-derived islet-like clusters
E Zanfrini, M Bandral, L Jarc, MA Ramirez-Torres… - Scientific Reports, 2024 - nature.com
The significant advances in the differentiation of human pluripotent stem (hPS) cells into
pancreatic endocrine cells, including functional β-cells, have been based on a detailed …
pancreatic endocrine cells, including functional β-cells, have been based on a detailed …
Concise review: making and using clinically compliant pluripotent stem cell lines
MK Carpenter, MS Rao - Stem cells translational medicine, 2015 - academic.oup.com
The field of pluripotent stem cells (PSCs) is in a state of dynamic flux driven by significant
advances in the derivation of specific phenotypes from embryonic stem cells, breakthroughs …
advances in the derivation of specific phenotypes from embryonic stem cells, breakthroughs …
Fish genome manipulation and directional breeding
D Ye, ZY Zhu, YH Sun - Science China Life Sciences, 2015 - Springer
Aquaculture is one of the fastest develo** agricultural industries worldwide. One of the
most important factors for sustainable aquaculture is the development of high performing …
most important factors for sustainable aquaculture is the development of high performing …