2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on …

PA Heidenreich, B Bozkurt, D Aguilar, LA Allen… - Journal of the American …, 2022 - jacc.org
Abstract Aim The “2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure”
replaces the “2013 ACCF/AHA Guideline for the Management of Heart Failure” and the …

Chemotherapy side-effects: not all DNA damage is equal

WMC van den Boogaard, DSJ Komninos, WP Vermeij - Cancers, 2022 - mdpi.com
Simple Summary The number of children and adults with cancer that are completely cured is
still increasing thanks to effective anti-cancer therapy, but they may be confronted with the …

Doxorubicin prodrug-based nanomedicines for the treatment of cancer

H Zhao, J Yu, R Zhang, P Chen, H Jiang… - European journal of …, 2023 - Elsevier
The chemotherapeutic drug of doxorubicin (DOX) has witnessed widespread applications
for treating various cancers. DOX-treated dying cells bear cellular modifications which allow …

Cardiotoxicity of anticancer drugs: molecular mechanisms and strategies for cardioprotection

MB Morelli, C Bongiovanni, S Da Pra… - Frontiers in …, 2022 - frontiersin.org
Chemotherapy and targeted therapies have significantly improved the prognosis of
oncology patients. However, these antineoplastic treatments may also induce adverse …

Contribution to tumor angiogenesis from innate immune cells within the tumor microenvironment: implications for immunotherapy

A Albini, A Bruno, DM Noonan, L Mortara - Frontiers in immunology, 2018 - frontiersin.org
The critical role of angiogenesis in promoting tumor growth and metastasis is strongly
established. However, tumors show considerable variation in angiogenic characteristics and …

Molecular mechanism involved in cyclophosphamide-induced cardiotoxicity: Old drug with a new vision

A Iqubal, MK Iqubal, S Sharma, MA Ansari, AK Najmi… - Life sciences, 2019 - Elsevier
Cyclophosphamide (CP) is an important anticancer drug which belongs to the class of
alkylating agent. Cyclophosphamide is mostly used in bone marrow transplantation …

Breast cancer survivorship: a comprehensive review of long-term medical issues and lifestyle recommendations

BI Bodai, P Tuso - The Permanente Journal, 2015 - pmc.ncbi.nlm.nih.gov
Long-term survival rates after a diagnosis of breast cancer are steadily rising. This is good
news, but clinicians must also recognize that this brings new challenges to the medical …

Systematic analysis of drug-associated myocarditis reported in the World Health Organization pharmacovigilance database

LS Nguyen, LT Cooper, M Kerneis… - Nature …, 2022 - nature.com
While multiple pharmacological drugs have been associated with myocarditis, temporal
trends and overall mortality have not been reported. Here we report the spectrum and main …

Anthracycline-induced cardiotoxicity in the chemotherapy treatment of breast cancer: Preventive strategies and treatment

F Cai, MAF Luis, X Lin, M Wang… - Molecular and …, 2019 - spandidos-publications.com
Anthracyclines are highly effective chemotherapeutic agents, used for a wide variety of
malignancies. Cardiotoxicity is a well-recognized side effect of anthracycline therapy that …

Cancer-activated doxorubicin prodrug nanoparticles induce preferential immune response with minimal doxorubicin-related toxicity

S Yang, MK Shim, WJ Kim, J Choi, GH Nam, J Kim… - Biomaterials, 2021 - Elsevier
The effective chemotherapeutic drug, doxorubicin (DOX), elicits immunogenic cell death
(ICD) and additional anticancer immune responses during chemotherapy. However, it also …