Beneath the complexity and idiopathy of every cancer lies a limited number of'mission
critical'events that have propelled the tumour cell and its progeny into uncontrolled …

With rapid advances in sequencing technologies, tremendous progress has been made in
understanding the molecular pathogenesis of acute myeloid leukaemia (AML), thus …

Every cell in a multicellular organism has the potential to die by apoptosis, but tumour cells
often have faulty apoptotic pathways. These defects not only increase tumour mass, but also …

The ability of a cell to undergo mitochondrial apoptosis is governed by pro-and anti-
apoptotic members of the BCL-2 protein family. The equilibrium of pro-versus anti-apoptotic …

The ability of cancer cells to suppress apoptosis is critical for carcinogenesis. The BCL2
family proteins comprise the sentinel network that regulates the mitochondrial or intrinsic …

Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the
second most common form of acute leukemia in children. Despite this, very little …

Carcinogenesis is a mechanistically complex and variable process with a plethora of
underlying genetic causes. Cancer development comprises a multitude of steps that occur …

The MCL1 gene is frequently amplified in cancer and codes for the antiapoptotic protein
myeloid cell leukemia 1 (MCL1), which confers resistance to the current standard of care …

BCL-2 proteins are critical for cell survival and are overexpressed in many tumors. ABT-737
is a small-molecule BH3 mimetic that exhibits single-agent activity against lymphoma and …

Each day, approximately 50 to 70 billion cells perish in the average adult because of
programmed cell death (PCD). Cell death in self-renewing tissues, such as the skin, gut, and …