The tubulin code and its role in controlling microtubule properties and functions

C Janke, MM Magiera - Nature Reviews Molecular Cell Biology, 2020 - nature.com
Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, sha**, motility and intracellular transport. Despite their functional heterogeneity …

The tubulin code in microtubule dynamics and information encoding

A Roll-Mecak - Developmental cell, 2020 - cell.com
Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton.
Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin …

Mechanosensitive ion channels: structural features relevant to mechanotransduction mechanisms

P **, LY Jan, YN Jan - Annual review of neuroscience, 2020 - annualreviews.org
Activation of mechanosensitive ion channels underlies a variety of fundamental
physiological processes that require sensation of mechanical force. Different …

[HTML][HTML] Microtubule control of functional architecture in neurons

MT Kelliher, HAJ Saunders, J Wildonger - Current opinion in neurobiology, 2019 - Elsevier
Highlights•Regulation of non-centrosomal microtubule organization in neurons.•Role of
resilient acetylated microtubules in mechanosensation.•Patterning microtubule tracks to …

Tubulin post-translational modifications: the elusive roles of acetylation

B Carmona, HS Marinho, CL Matos, S Nolasco… - Biology, 2023 - mdpi.com
Simple Summary Microtubules (MTs) are dynamic structures that compose part of the cell
cytoskeleton. They play important roles in various cellular functions, such as intracellular …

Tubulin post‐translational modifications control neuronal development and functions

MJ Moutin, C Bosc, L Peris… - Developmental …, 2021 - Wiley Online Library
Microtubules (MTs) are an essential component of the neuronal cytoskeleton; they are
involved in various aspects of neuron development, maintenance, and functions including …

Force from filaments: the role of the cytoskeleton and extracellular matrix in the gating of mechanosensitive channels

YC Chuang, CC Chen - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
The senses of proprioception, touch, hearing, and blood pressure on mechanosensitive ion
channels that transduce mechanical stimuli with high sensitivity and speed. This conversion …

Acetylated α-tubulin K394 regulates microtubule stability to shape the growth of axon terminals

HAJ Saunders, DM Johnson-Schlitz, BV Jenkins… - Current Biology, 2022 - cell.com
Microtubules are essential to neuron shape and function. Acetylation of tubulin has the
potential to directly tune the behavior and function of microtubules in cells. Although …

Cardiomyocyte microtubules: control of mechanics, transport, and remodeling

K Uchida, EA Scarborough… - Annual review of …, 2022 - annualreviews.org
Microtubules are essential cytoskeletal elements found in all eukaryotic cells. The structure
and composition of microtubules regulate their function, and the dynamic remodeling of the …

Mechanical forces orchestrate brain development

M Javier-Torrent, G Zimmer-Bensch, L Nguyen - Trends in Neurosciences, 2021 - cell.com
During brain development, progenitors generate successive waves of neurons that populate
distinct cerebral regions, where they settle and differentiate within layers or nuclei. While …