Activation of the p53 tumor suppressor can lead to cell cycle arrest. The key mechanism of
p53-mediated arrest is transcriptional downregulation of many cell cycle genes. In recent …

The ubiquitin proteasome system (UPS) degrades individual proteins in a highly regulated
fashion and is responsible for the degradation of misfolded, damaged, or unneeded cellular …

Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug
research. A common approach is to infer signaling activity of pathways from gene …

Efficient S phase entry is essential for development, tissue repair, and immune defences.
However, hyperactive or expedited S phase entry causes replication stress, DNA damage …

Abnormal increases in cell size are associated with senescence and cell cycle exit. The
mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain …

Following DNA damage caused by exogenous sources, such as ionizing radiation, the
tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21 …

Mitogen-dependent progression through the first gap phase (G1) and initiation of DNA
synthesis (S phase) during the mammalian cell division cycle are cooperatively regulated by …

Tumour recurrence is a serious impediment to cancer treatment, but the mechanisms
involved are poorly understood. The most frequently used anti-tumour therapies …

Uncontrolled cell proliferation is the hallmark of cancer, and tumor cells have typically
acquired damage to genes that directly regulate their cell cycles. Genetic alterations …

Whitehead Institute for Biomedical Research Massachusetts Institute of Technology
Cambridge, Massachusetts 02142 pRB, the product of the retinoblastoma tumor suppressor …