Extracellular vesicles (EVs) are heterogeneous, phospholipid bilayer‐enclosed biological
particles that regulate cell communication by molecular cargo delivery and surface …

Skin, our first interface to the external environment, is subjected to oxidative stress caused
by a variety of factors such as solar ultraviolet, infrared and visible light, environmental …

Tyrosinase is a multifunctional glycosylated and copper-containing oxidase that is highly
prevalent in plants and animals and plays a pivotal role in catalyzing the two key steps of …

Melanins are pigment molecules that determine the skin, eye, and hair color of the human
subject to its amount, quality, and distribution. Melanocytes synthesize melanin and provide …

Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …

Human skin, eye and hair color rely on the production of melanin, depending on its quantity,
quality, and distribution, Melanin plays a monumental role in protecting the skin against the …

Hyperpigmentation is a common and distressing dermatologic condition. Since tyrosinase
(TYR) plays an essential role in melanogenesis, its inhibition is considered a logical …

Consumer interest in cosmetic industry products that produce whitening effects has
increased demand for agents that decrease melanin production. Many such anti …

Melanin, the compound primarily responsible in humans for hair, eye and skin pigmentation,
is produced by melanocytes through a complicated process called melanogenesis that is …

Abnormally high production of melanin or melanogenesis in skin melanocytes results in
hyperpigmentation disorders, such as melasma, senile lentigines or freckles. These …