This review has been centralized on applications of phthalic anhydride (PA) as a valuable
and significant heterocyclic substrate in two-and multicomponent organic reactions. The …

Thalidomide and its analogs are immunomodulatory drugs that inhibit the production of
certain inflammatory mediators associated with cancer. In the present work, a new series of …

ABSTRACT Isoindoline-1, 3-dione, also referred as phthalimide, has gained recognition as
promising pharmacophore due to the documented biological activities of its derivatives …

Lappaconitine (LA), a natural compound with a novel C18-diterpenoid alkaloid skeleton,
displayed extensive biological profile. Recent research on LA is focused mainly on its anti …

Sepsis is often caused by systemic inflammatory responses. Stimulator of interferon genes
(STING) could be a promising treatment target for sepsis. In this study, we report the design …

Cancer remains a high incidence and mortality disease, causing around 8.2 million of
deaths in the last year. Current chemotherapy needs to be expanded, making research for …

Background: Privileged motifs are recurring in a wide range of biologically active
compounds that reach different pharmaceutical targets and pathways and could represent a …

Chagas disease is a parasitic infection caused by protozoan Trypanosoma cruzi that affects
approximately 6–7 million people worldwide. Benznidazole is the only drug approved for …

Sinomenine (SIN) has long been known as an anti-inflammatory drug, while poor efficiency
and large-dose treatment had limited its further application. A series of novel SIN derivatives …

The strategy of antiangiogenic drugs is based on inhibiting formation of new blood vessels
as alternative to limit cancer progression. In this work, we investigated the antitumor and …