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Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets
Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
A concise review on recent development of indole derivatives for anticancer activities
Indole heterocycles have been considered as noteworthy associated hybrids because of
their diverse applications in organic synthesis, and coordination chemistry, as well as in the …
their diverse applications in organic synthesis, and coordination chemistry, as well as in the …
Development of chromone-thiazolidine-2, 4-dione Knoevenagel conjugates as apoptosis inducing agents
MS Galla, NB Kale, A Sharma, A Hajare… - Bioorganic & Medicinal …, 2024 - Elsevier
Overexpression of Bcl-2 protein is a predominant hallmark of disturbed apoptotic pathway in
most of the cancers. Herein, chromone-linked thiazolidinediones were designed and …
most of the cancers. Herein, chromone-linked thiazolidinediones were designed and …
Development of 3-indolyl substituted phenyl pyrazolo-carboxamide hybrids as potential type II VEGFR-2 inhibitors and in vitro cytotoxicity studies
DG Valapil, G Devabattula, AS Barahdia… - Bioorganic & Medicinal …, 2025 - Elsevier
The progression of tumors is intricately linked to angiogenesis, the formation of new blood
vessels, driven primarily by the release of growth factors such as Vascular Endothelial …
vessels, driven primarily by the release of growth factors such as Vascular Endothelial …