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Functions and mechanisms of non-histone protein acetylation
N ε-lysine acetylation was discovered more than half a century ago as a post-translational
modification of histones and has been extensively studied in the context of transcription …
modification of histones and has been extensively studied in the context of transcription …
The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communication
How distal cis-regulatory elements (eg, enhancers) communicate with promoters remains an
unresolved question of fundamental importance. Although transcription factors and cofactors …
unresolved question of fundamental importance. Although transcription factors and cofactors …
Interindividual variability in transgene mRNA and protein production following adeno-associated virus gene therapy for hemophilia A
Factor VIII gene transfer with a single intravenous infusion of valoctocogene roxaparvovec
(AAV5-hFVIII-SQ) has demonstrated clinical benefits lasting 5 years to date in people with …
(AAV5-hFVIII-SQ) has demonstrated clinical benefits lasting 5 years to date in people with …
Histone acetyltransferases
▪ Abstract Transcriptional regulation in eukaryotes occurs within a chromatin setting and is
strongly influenced by nucleosomal barriers imposed by histone proteins. Among the well …
strongly influenced by nucleosomal barriers imposed by histone proteins. Among the well …
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth
Most tumor cells take up more glucose than normal cells but metabolize glucose via
glycolysis even in the presence of normal levels of oxygen, a phenomenon known as the …
glycolysis even in the presence of normal levels of oxygen, a phenomenon known as the …
Nuclear hormone receptors and gene expression
A Aranda, A Pascual - Physiological reviews, 2001 - journals.physiology.org
The nuclear hormone receptor superfamily includes receptors for thyroid and steroid
hormones, retinoids and vitamin D, as well as different “orphan” receptors of unknown …
hormones, retinoids and vitamin D, as well as different “orphan” receptors of unknown …
[HTML][HTML] Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
Abstract High Mobility Group 1 protein (HMGB1) is a chromatin component that, when
leaked out by necrotic cells, triggers inflammation. HMGB1 can also be secreted by activated …
leaked out by necrotic cells, triggers inflammation. HMGB1 can also be secreted by activated …
Hepatocyte nuclear factor 4α (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis
GP Hayhurst, YH Lee, G Lambert, JM Ward… - … and cellular biology, 2001 - Taylor & Francis
The numerous functions of the liver are controlled primarily at the transcriptional level by the
concerted actions of a limited number of hepatocyte-enriched transcription factors …
concerted actions of a limited number of hepatocyte-enriched transcription factors …
p300/CBP proteins: HATs for transcriptional bridges and scaffolds
p300/CBP transcriptional co-activator proteins play a central role in co-ordinating and
integrating multiple signal-dependent events with the transcription apparatus, allowing the …
integrating multiple signal-dependent events with the transcription apparatus, allowing the …
Duration of nuclear NF-κB action regulated by reversible acetylation
The nuclear expression and action of the nuclear factor kappa B (NF-κB) transcription factor
requires signal-coupled phosphorylation and degradation of the IκB inhibitors, which …
requires signal-coupled phosphorylation and degradation of the IκB inhibitors, which …