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P-glycoprotein: New insights into structure, physiological function, regulation and alterations in disease
The multidrug resistance phenomenon presents a major threat to the pharmaceutical
industry. This resistance is a common occurrence in several diseases and is mediated by …
industry. This resistance is a common occurrence in several diseases and is mediated by …
Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges
Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …
human neonates, and is often associated with persistent motor, sensory, and cognitive …
Role of prenatal hypoxia in brain development, cognitive functions, and neurodegeneration
This review focuses on the role of prenatal hypoxia in the development of brain functions in
the postnatal period and subsequent increased risk of neurodegenerative disorders in later …
the postnatal period and subsequent increased risk of neurodegenerative disorders in later …
The physiology of intrapartum fetal compromise at term
Uterine contractions in labor result in a 60% reduction in uteroplacental perfusion, causing
transient fetal and placental hypoxia. A healthy term fetus with a normally developed …
transient fetal and placental hypoxia. A healthy term fetus with a normally developed …
[HTML][HTML] Spreading depolarization is not an epiphenomenon but the principal mechanism of the cytotoxic edema in various gray matter structures of the brain during …
Spreading depolarization (SD) is a phenomenon of various cerebral gray matter structures
that only occurs under pathological conditions. In the present paper, we summarize the …
that only occurs under pathological conditions. In the present paper, we summarize the …
Roles of reactive oxygen and nitrogen species in pain
Peroxynitrite (PN; ONOO−) and its reactive oxygen precursor superoxide (SO; O2•−) are
critically important in the development of pain of several etiologies including pain associated …
critically important in the development of pain of several etiologies including pain associated …
Neuroscience nanotechnology: progress, opportunities and challenges
Nanotechnologies exploit materials and devices with a functional organization that has been
engineered at the nanometre scale. The application of nanotechnology in cell biology and …
engineered at the nanometre scale. The application of nanotechnology in cell biology and …
Causes of oxidative stress in the pre-and perinatal period
Oxidative stress may be defined as an imbalance between pro-oxidant and antioxidant
forces resulting in an overall pro-oxidant insult. Pregnancy is a physiological state …
forces resulting in an overall pro-oxidant insult. Pregnancy is a physiological state …
Migraine Aura, transient ischemic attacks, stroke, and dying of the brain share the same key pathophysiological process in neurons driven by Gibbs–Donnan forces …
CL Lemale, J Lückl, V Horst, C Reiffurth… - Frontiers in cellular …, 2022 - frontiersin.org
Neuronal cytotoxic edema is the morphological correlate of the near-complete neuronal
battery breakdown called spreading depolarization, or conversely, spreading depolarization …
battery breakdown called spreading depolarization, or conversely, spreading depolarization …
Oxidative stress in preterm neonates at birth and on the seventh day of life
Previous studies have demonstrated increased oxidative damage to proteins and increased
lipid peroxidation products in the plasma of hypoxic newborns at birth. We tested the …
lipid peroxidation products in the plasma of hypoxic newborns at birth. We tested the …