Biomolecular recognition is versatile, specific, and high affinity, qualities that have motivated
decades of research aimed at adapting biomolecules into a general platform for molecular …

Protein switches are ubiquitous in biological signal transduction systems, enabling cells to
sense and respond to a variety of molecular queues in a rapid, specific, and integrated …

Protein engineers traditionally rely on amino acid substitutions to alter the functional
properties of biomacromolecules, yet have largely overlooked the potential benefits of …

Chemosensing in nature relies on biomolecular switches, biomolecules that undergo
binding-induced changes in conformation or oligomerization to transduce chemical …

Protein conformational switches alter their shape upon receiving an input signal, such as
ligand binding, chemical modification, or change in environment. The apparent simplicity of …

Although the ability to monitor specific molecules in vivo in real-time could revolutionize
many aspects of healthcare, the technological challenges that stand in the way of reaching …

Biomolecular recognition has long been an important theme in artificial sensing
technologies. A current limitation of protein-and nucleic acid-based recognition, however, is …

The transduction of biological signals often involves structural rearrangements of proteins in
response to input signals, which leads to functional outputs. This review discusses the role …

In optogenetics, light-sensitive proteins are specifically expressed in target cells and light is
used to precisely control the activity of these proteins at high spatiotemporal resolution …

Naturally occurring chemoreceptors almost invariably employ structure-switching
mechanisms, an observation that has inspired the use of biomolecular switches in a wide …