Methods and compositions for nucleic acid analysis
S Saxonov - US Patent 9,347,059, 2016 - Google Patents
Provided herein are methods, compositions, and kits for assays, many of which involve
amplification reactions such as digital PCR or droplet digital PCR. The assays may be used …
amplification reactions such as digital PCR or droplet digital PCR. The assays may be used …
Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from
Thermus aquaticus strain HB8, and the use of this ligase in a ligase chain reaction (LCR) …
Thermus aquaticus strain HB8, and the use of this ligase in a ligase chain reaction (LCR) …
Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
F Barany, M Lubin - US Patent 6,027,889, 2000 - Google Patents
The present invention relates to the detection of nucleic acid sequence differences using
coupled ligase detection reaction and polymerase chain reaction. One aspect of the present …
coupled ligase detection reaction and polymerase chain reaction. One aspect of the present …
Nucleic acid analysis techniques
DJ Lockhart, M Chee, K Gunderson… - US Patent …, 2002 - Google Patents
1998-04-24 Assigned to AFFYMETRIX INC. reassignment AFFYMETRIX INC. ASSIGNMENT
OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BARONE …
OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BARONE …
Single cell bar-coding for antibody discovery
G01N33/5008—Chemical analysis of biological material, eg blood, urine; Testing involving
biospecific ligand binding methods; Immunological testing involving human or animal cells …
biospecific ligand binding methods; Immunological testing involving human or animal cells …
Multiplex nucleic acid reactions
A Oliphant, JR Stuelpnagel, MS Chee… - US Patent …, 2009 - Google Patents
US7582420B2 - Multiplex nucleic acid reactions - Google Patents US7582420B2 - Multiplex
nucleic acid reactions - Google Patents Multiplex nucleic acid reactions Download PDF Info …
nucleic acid reactions - Google Patents Multiplex nucleic acid reactions Download PDF Info …
Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
The present invention describes a method for identifying one or more of a plurality of
Sequences differing by one or more Single base changes, insertions, deletions, or …
Sequences differing by one or more Single base changes, insertions, deletions, or …
Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
The present invention relates to a method for identifying a target nucleotide sequence. This
method involves forming a ligation product on a target nucleotide sequence in a ligase …
method involves forming a ligation product on a target nucleotide sequence in a ligase …
Circularizing nucleic acid probe able to interlock with a target sequence through catenation
U Landegren, M Kwiatkowski - US Patent 5,871,921, 1999 - Google Patents
The invention relates to a method of detecting a target nucleic acid sequence in a sample by
contacting the sample With a detectable probe having ends Which hybridize to tWo adjacent …
contacting the sample With a detectable probe having ends Which hybridize to tWo adjacent …
Coupled amplification and ligation method
F Eggerding - US Patent 5,912,148, 1999 - Google Patents
Amethod based on polymerase chain reaction (PCR) ampli? cation and oligonucleotide
ligase assay (OLA) reaction is provided for analyzing complex genetic systems in a single …
ligase assay (OLA) reaction is provided for analyzing complex genetic systems in a single …