Assembly-line polyketide synthases (PKSs) are among the most complex protein
machineries known in nature, responsible for the biosynthesis of numerous compounds …

Cryptosporidium is a protozoan parasite of medical and veterinary importance that causes
gastroenteritis in a variety of vertebrate hosts. Several studies have reported different …

Abstract Molecular Lego: Polyketides represent a highly diverse group of natural products
with structurally intriguing carbon skeletons (see picture) which are assembled from simple …

Fungi contain a remarkable diversity of both primary and secondary metabolic pathways
involved in ecologically specialized or accessory functions. Genes in these pathways are …

The apicomplexan Cryptosporidium parvum is an intestinal parasite that affects healthy
humans and animals, and causes an unrelenting infection in immunocompromised …

Recent literature on polyketide biosynthesis suggests that polyketide synthases have much
greater diversity in both mechanism and structure than the current type I, II and III paradigms …

Hepatocellular carcinoma is generally refractory to clinical treatment. Here, we report that
inactivation of the MYC oncogene is sufficient to induce sustained regression of invasive …

Nonribosomal peptide synthetases (NRPS) and type I polyketide synthases (PKS-I) are
biosynthetic systems involved in the synthesis of a large number of important biologically …

Cryptosporidium species cause acute gastroenteritis and diarrhoea worldwide. They are
members of the Apicomplexa—protozoan pathogens that invade host cells by using a …

The apicomplexan parasite Cryptosporidium is a leading global cause of severe diarrhoeal
disease and an important contributor to early childhood mortality. Currently, there are no …