This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

In this review, we provide an overview of the current understanding of the main mechanisms
of pharmacological action of essential oils and their components in various biological …

The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in
the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Introduction Chronic pain affects approximatively 30–50% of the population globally.
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …

The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive
impairment and affects all levels of the brain's vasculature. Features include diverse …

The transient receptor potential vanilloid 1 and ankyrin 1 (TRPV1 and TRPA1, respectively)
channels are members of the TRP superfamily of structurally related, non‐selective cation …

Abstract The Transient Receptor Potential Ankyrin 1 channel (TRPA1), is a member of the
large TRP family of ion channels, and functions as a Ca 2+ permeable non-selective cation …