Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …

The number of protein-based drugs is exponentially increasing. However, development of
protein therapeutics against intracellular targets is hampered by the lack of efficient cytosolic …

The delivery of functional proteins remains a major challenge in advancing biological and
pharmaceutical sciences. Herein, we describe a powerful, simple, and highly effective …

Fc region binding peptide conjugated with attenuated cationic amphiphilic lytic peptide L17E
trimer [FcB (L17E) 3] was designed for immunoglobulin G (IgG) delivery into cells. Particle …

Intracellular delivery of protein therapeutics remains a significant challenge limiting the
majority of clinically available protein drugs to extracellular targets. Strategies to deliver …

Nanocarriers that deliver functional proteins to cell interiors are an attractive platform for the
intracellular delivery of intact proteins without further modification, with in vivo compatibility …

The development of a cytosolic delivery strategy for biopharmaceuticals is one of the central
issues in drug development. Knowledge of the mechanisms underlying these processes …

Although proteins have attractive features as biopharmaceuticals, the difficulty in delivering
them into the cell interior limits their applicability. Lipid nanoparticles (LNPs) are a promising …

Cell-penetrating peptides represent an emerging class of carriers capable of effective
cellular delivery. This work demonstrates the preparation and investigation of efficient CPPs …

Macropinocytosis is a form of endocytosis that allows massive uptake of extracellular
materials and is a promising route for intracellular delivery of biofunctional macromolecules …