Genome-editing technologies: concept, pros, and cons of various genome-editing techniques and bioethical concerns for clinical application
SH Khan - Molecular Therapy-Nucleic Acids, 2019 - cell.com
The traditional healthcare system is at the doorstep for entering into the arena of molecular
medicine. The enormous knowledge and ongoing research have now been able to …
medicine. The enormous knowledge and ongoing research have now been able to …
PAM identification by CRISPR-Cas effector complexes: diversified mechanisms and structures
Adaptive immunity of prokaryotes is mediated by CRISPR-Cas systems that employ a large
variety of Cas protein effectors to identify and destroy foreign genetic material. The different …
variety of Cas protein effectors to identify and destroy foreign genetic material. The different …
RNA-guided editing of bacterial genomes using CRISPR-Cas systems
Here we use the clustered, regularly interspaced, short palindromic repeats (CRISPR)–
associated Cas9 endonuclease complexed with dual-RNAs to introduce precise mutations …
associated Cas9 endonuclease complexed with dual-RNAs to introduce precise mutations …
CRISPR interference (CRISPRi) for sequence-specific control of gene expression
Sequence-specific control of gene expression on a genome-wide scale is an important
approach for understanding gene functions and for engineering genetic regulatory systems …
approach for understanding gene functions and for engineering genetic regulatory systems …
CRISPR-Cas systems and methods for altering expression of gene products
F Zhang - US Patent 8,697,359, 2014 - Google Patents
The invention provides for systems, methods, and compositions for altering expression of
target gene sequences and related gene products. Provided are vectors and vector systems …
target gene sequences and related gene products. Provided are vectors and vector systems …
CRISPR-Cas component systems, methods and compositions for sequence manipulation
F Zhang - US Patent 8,795,965, 2014 - Google Patents
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CRISPR-Cas component systems, methods and compositions for sequence manipulation
L Cong, F Zhang - US Patent 8,871,445, 2014 - Google Patents
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CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes
L Cong, F Zhang - US Patent 8,932,814, 2015 - Google Patents
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Engineering of systems, methods and optimized guide compositions for sequence manipulation
The invention provides for systems, methods, and compositions for manipulation of
sequences and/or activities of target sequences. Provided are vectors and vector systems …
sequences and/or activities of target sequences. Provided are vectors and vector systems …
CRISPR-Cas systems and methods for altering expression of gene products
F Zhang - US Patent 8,771,945, 2014 - Google Patents
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