Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages …

Embryo-derived tissue-resident macrophages are the first representatives of the
haematopoietic lineage to emerge in metazoans. In mammals, resident macrophages …

The immune system of the central nervous system (CNS) consists primarily of innate
immune cells. These are highly specialized macrophages found either in the parenchyma …

Neuroinflammation, a protective response of the central nervous system (CNS), is
associated with the pathogenesis of neurodegenerative diseases. The CNS is composed of …

The innate immune system has the capacity to detect 'non-self'molecules derived from
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …

Triggering receptor expressed on myeloid cells 2 (TREM2) is strongly linked to Alzheimer's
disease (AD) risk, but its functions are not fully understood. Here, we found that TREM2 …

Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease
of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are …

Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

Summary Loss-of-function (LOF) variants of TREM2, an immune receptor expressed in
microglia, increase Alzheimer's disease risk. TREM2 senses lipids and mediates myelin …

Microglia were first recognized as a distinct cell population in the CNS one century ago. For
a long time, they were primarily considered to be phagocytes responsible for removing …