Representation learning applications in biological sequence analysis

H Iuchi, T Matsutani, K Yamada, N Iwano… - Computational and …, 2021 - Elsevier
Although remarkable advances have been reported in high-throughput sequencing, the
ability to aptly analyze a substantial amount of rapidly generated biological …

Common methods for phylogenetic tree construction and their implementation in R

Y Zou, Z Zhang, Y Zeng, H Hu, Y Hao, S Huang, B Li - Bioengineering, 2024 - mdpi.com
A phylogenetic tree can reflect the evolutionary relationships between species or gene
families, and they play a critical role in modern biological research. In this review, we …

GeoPhy: differentiable phylogenetic inference via geometric gradients of tree topologies

T Mimori, M Hamada - Advances in Neural Information …, 2023 - proceedings.neurips.cc
Phylogenetic inference, grounded in molecular evolution models, is essential for
understanding the evolutionary relationships in biological data. Accounting for the …

A machine-learning-based alternative to phylogenetic bootstrap

N Ecker, D Huchon, Y Mansour, I Mayrose… - …, 2024 - academic.oup.com
Motivation Currently used methods for estimating branch support in phylogenetic analyses
often rely on the classic Felsenstein's bootstrap, parametric tests, or their approximations. As …

[HTML][HTML] Learning hyperbolic embedding for phylogenetic tree placement and updates

Y Jiang, P Tabaghi, S Mirarab - Biology, 2022 - mdpi.com
Simple Summary We show how the conventional (Euclidean) deep learning methods
developed for phylogenetics can benefit from using hyperbolic geometry. The results point to …

Hyperbolic optimizer as a dynamical system

N Alvarado, H Lobel - Forty-first International Conference on …, 2024 - openreview.net
During the last few years, the field of dynamical systems has been develo** innovative
tools to study the asymptotic behavior of different optimizers in the context of neural …

Lea** through tree space: continuous phylogenetic inference for rooted and unrooted trees

MJ Penn, N Scheidwasser, J Penn… - Genome Biology and …, 2023 - academic.oup.com
Phylogenetics is now fundamental in life sciences, providing insights into the earliest
branches of life and the origins and spread of epidemics. However, finding suitable …

Fidelity of hyperbolic space for Bayesian phylogenetic inference

M Macaulay, A Darling, M Fourment - PLoS computational biology, 2023 - journals.plos.org
Bayesian inference for phylogenetics is a gold standard for computing distributions of
phylogenies. However, Bayesian phylogenetics faces the challenging computational …

On procrustes analysis in hyperbolic space

P Tabaghi, I Dokmanić - IEEE Signal Processing Letters, 2021 - ieeexplore.ieee.org
Congruent Procrustes analysis aims to find the best matching between two point sets
through rotation, reflection and translation. We formulate the Procrustes problem for …

Variational Bayesian phylogenies through matrix representation of tree space

RR Bouckaert - PeerJ, 2024 - peerj.com
In this article, we study the distance matrix as a representation of a phylogeny by way of
hierarchical clustering. By defining a multivariate normal distribution on (a subset of) the …