Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

C Gao, J Jiang, Y Tan, S Chen - Signal transduction and targeted …, 2023 - nature.com
Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

[HTML][HTML] Neurocognitive, physiological, and biophysical effects of transcranial alternating current stimulation

M Wischnewski, I Alekseichuk, A Opitz - Trends in Cognitive Sciences, 2023 - cell.com
Transcranial alternating current stimulation (tACS) can modulate human neural activity and
behavior. Accordingly, tACS has vast potential for cognitive research and brain disorder …

Multisensory gamma stimulation promotes glymphatic clearance of amyloid

MH Murdock, CY Yang, N Sun, PC Pao… - Nature, 2024 - nature.com
The glymphatic movement of fluid through the brain removes metabolic waste,,–.
Noninvasive 40 Hz stimulation promotes 40 Hz neural activity in multiple brain regions and …

Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance

LF Jiang-**e, A Drieu, K Bhasiin, D Quintero, I Smirnov… - Nature, 2024 - nature.com
The accumulation of metabolic waste is a leading cause of numerous neurological
disorders, yet we still have only limited knowledge of how the brain performs self-cleansing …

Forty-hertz light stimulation does not entrain native gamma oscillations in Alzheimer's disease model mice

M Soula, A Martín-Ávila, Y Zhang, A Dhingra… - Nature …, 2023 - nature.com
There is a demand for noninvasive methods to ameliorate disease. We investigated whether
40-Hz flickering light entrains gamma oscillations and suppresses amyloid-β in the brains of …

Precuneus magnetic stimulation for Alzheimer's disease: a randomized, sham-controlled trial

G Koch, EP Casula, S Bonnì, I Borghi, M Assogna… - Brain, 2022 - academic.oup.com
Repetitive transcranial magnetic stimulation (rTMS) is emerging as a non-invasive
therapeutic strategy in the battle against Alzheimer's disease. Alzheimer's disease patients …

Immune activation in Alzheimer disease

A Mary, R Mancuso, MT Heneka - Annual Review of …, 2024 - annualreviews.org
Alzheimer disease (AD) is the most common neurodegenerative disease, and with no
efficient curative treatment available, its medical, social, and economic burdens are …

Challenges and hopes for Alzheimer's disease

SA Tatulian - Drug discovery today, 2022 - Elsevier
Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …

Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level

ECB Johnson, EK Carter, EB Dammer, DM Duong… - Nature …, 2022 - nature.com
The biological processes that are disrupted in the Alzheimer's disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …

[HTML][HTML] Gamma frequency sensory stimulation in mild probable Alzheimer's dementia patients: Results of feasibility and pilot studies

D Chan, HJ Suk, BL Jackson, NP Milman, D Stark… - PloS one, 2022 - journals.plos.org
Non-invasive Gamma ENtrainment Using Sensory stimulation (GENUS) at 40Hz reduces
Alzheimer's disease (AD) pathology such as amyloid and tau levels, prevents cerebral …