Numerous mitochondrial constituents and metabolic products can function as damage-
associated molecular patterns (DAMPs) and promote inflammation when released into the …

In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …

Few metabolites can claim a more central and versatile role in cell metabolism than acetyl
coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the …

Tumor immunotherapy is only effective in a fraction of patients due to a low response rate
and severe side effects, and these challenges of immunotherapy in clinics can be addressed …

Dying mammalian cells emit numerous signals that interact with the host to dictate the
immunological correlates of cellular stress and death. In the absence of reactive antigenic …

The progression of cancer involves a critical step in which malignant cells escape from
control by the immune system. Antineoplastic agents are particularly efficient when they …

Breast cancers are complex ecosystems of malignant cells and the tumour
microenvironment. The composition of these tumour ecosystems and interactions within …

Accumulating evidence suggests that metabolic rewiring in malignant cells supports tumour
progression not only by providing cancer cells with increased proliferative potential and an …

Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Immunogenic cell death (ICD), which results from insufficient cellular adaptation to specific
stressors, occupies a central position in the development of novel anticancer treatments …