Type I interferons (IFNs)(IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties,
including induction by viral infection, activation of shared signaling pathways, and …

When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …

Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …

Modern humans inhabit a variety of environments and are exposed to a plethora of selective
pressures, leading to multiple genetic adaptations to local environmental conditions. These …

Objective The clinical significance of polymorphisms in the interleukin-28B gene encoding
interferon (IFN)-λ3, which has antiviral effects, is known in chronic HCV but not in HBV …

Much progress has been made in the identification of specific human gene variants that
contribute to enhanced susceptibility or resistance to viral diseases. Herein we review …

The interferon system protects mammals against virus infections. There are several types of
interferons, which are characterized by their ability to inhibit virus replication and resultant …

Ambient temperature is a critical environmental factor for all living organisms. It was likely an
important selective force as modern humans recently colonized temperate and cold …

Balancing selection maintains advantageous diversity in populations through various
mechanisms. Although extensively explored from a theoretical perspective, an empirical …

Genome-wide association studies have identified several risk associations for ovarian
carcinomas but not for mucinous ovarian carcinomas (MOCs). Our analysis of 1,644 MOC …