Engineering cell metabolism for bioproduction not only consumes building blocks and
energy molecules (eg, ATP) but also triggers energetic inefficiency inside the cell. The …

Isoprenoids, often called terpenoids, are the most abundant and highly diverse family of
natural organic compounds. In plants, they play a distinct role in the form of photosynthetic …

Large-scale data acquisition and analysis are often required in the successful
implementation of the design, build, test, and learn (DBTL) cycle in biosystems design …

NADPH is an essential cofactor for the biosynthesis of several high-value chemicals,
including isoprenoids, fatty acid-based fuels, and biopolymers. Tunable control over all …

Metabolic engineering of microorganisms to produce sustainable chemicals has emerged
as an important part of the global bioeconomy. Unfortunately, efforts to design and engineer …

Quorum sensing (QS) is a ubiquitous cell–cell communication mechanism that can be
employed to autonomously and dynamically control metabolic fluxes. However, since the …

Optimization of metabolic pathways consisting of large number of genes is challenging.
Multivariate modular methods (MMMs) are currently available solutions, in which reduced …

The establishment of a heterologous pathway in a microbial host for the production of
industrially relevant chemicals at high titers and yields requires efficient adjustment of the …

Methods for simple and efficient regulation of metabolic pathway genes are essential for
maximizing product titers and conversion yields, and for minimizing the metabolic burden …

Terpenoids are a group of largest natural products with important biological functions, and
their efficient biosynthesis is of particular importance to both academia and industry. As the …