Non-alcoholic fatty liver disease has emerged a major challenge because of it prevalence,
difficulties in diagnosis, complex pathogenesis, and lack of approved therapies. As the …

Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …

Fat mass and obesity-associated gene (FTO) is a member of the Fe (II)-and oxoglutarate-
dependent AlkB dioxygenase family and is linked to both obesity and intellectual disability …

Similar to DNA epigenetic modifications, multiple reversible chemical modifications on RNAs
have been uncovered in a new layer of epigenetic modification. N6-methyladenosine (m6A) …

Abstract N 6-methyladenosine (m 6 A), catalyzed by the methyltransferase complex
consisting of Mettl3 and Mettl14, is the most abundant RNA modification in mRNAs and …

The 'obesity epidemic'represents a major global socioeconomic burden that urgently calls
for a better understanding of the underlying causes of increased weight gain and its …

Multiple theories identify neural vulnerability factors that may increase risk for overeating
and weight gain. Early cross-sectional neuroimaging studies were unable to determine …

Research over the past decade has provided strong support for the importance of various
epigenetic mechanisms, including DNA and histone modifications in regulating activity …

Epitranscriptomics, also known as “RNA epigenetics”, is a chemical modification for RNA
regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery …

RNA methylation is a post-transcriptional level of regulation. At present, more than 150 kinds
of RNA modifications have been identified. They are widely distributed in messenger RNA …