The cardinal stages of macroautophagy are driven by core autophagy‐related (ATG)
proteins, whose ablation largely abolishes intracellular turnover. Disrupting ATG genes is …

Macroautophagy, hereafter autophagy, is a degradative process conserved among
eukaryotes, which is essential to maintain cellular homeostasis. Defects in autophagy lead …

Despite the challenges posed by drug resistance and side effects, chemotherapy remains a
pivotal strategy in cancer treatment. A key issue in this context is macroautophagy …

The hallmark of non-selective autophagy is the formation of cup-shaped phagophores that
capture bulk cytoplasm. The process is accompanied by the conjugation of LC3B to …

The covalent conjugation of ubiquitin family proteins is a widespread post-translational
protein modification. In the ubiquitin family, the ATG8 subfamily is exceptional because it is …

ATG5 is a part of the E3 ligase directing lipidation of ATG8 proteins, a process central to
membrane atg8ylation and canonical autophagy. Loss of Atg5 in myeloid cells causes early …

Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

Autophagy is an essential catabolic pathway which sequesters and engulfs cytosolic
substrates via autophagosomes, unique double-membraned structures. ATG8 proteins are …

Autophagy is a lysosomal degradation system of cytoplasmic components that contributes to
cellular homeostasis through the turnover of various biomolecules and organelles, often in a …

Atg8, a ubiquitin-like protein, is conjugated with phosphatidylethanolamine (PE) via Atg7
(E1), Atg3 (E2) and Atg12–Atg5–Atg16 (E3) enzymatic cascade and mediates autophagy …