Placental origins of chronic disease
Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …
events during their intrauterine phase of development. Biologically this should not be …
Fetal growth restriction, catch-up growth and the early origins of insulin resistance and visceral obesity
There is an association between growing slowly before birth, accelerated growth in early
postnatal life and the emergence of insulin resistance, visceral obesity and glucose …
postnatal life and the emergence of insulin resistance, visceral obesity and glucose …
The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes
SR Thorn, PJ Rozance, LD Brown… - Seminars in …, 2011 - thieme-connect.com
The intrauterine growth restricted (IUGR) fetus develops unique metabolic adaptations in
response to exposure to reduced nutrient supply. These adaptations provide survival value …
response to exposure to reduced nutrient supply. These adaptations provide survival value …
A review of fundamental principles for animal models of DOHaD research: an Australian perspective
Epidemiology formed the basis of 'the Barker hypothesis', the concept of 'developmental
programming'and today's discipline of the Developmental Origins of Health and Disease …
programming'and today's discipline of the Developmental Origins of Health and Disease …
Impact of chronic hypoxemia on blood flow to the brain, heart, and adrenal gland in the late-gestation IUGR sheep fetus
R Poudel, IC McMillen, SL Dunn… - American Journal …, 2015 - journals.physiology.org
In the fetus, there is a redistribution of cardiac output in response to acute hypoxemia, to
maintain perfusion of key organs, including the brain, heart, and adrenal glands. There may …
maintain perfusion of key organs, including the brain, heart, and adrenal glands. There may …
Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction
LD Brown, PJ Rozance, JL Bruce… - American Journal …, 2015 - journals.physiology.org
Intrauterine growth-restricted (IUGR) fetal sheep, produced by placental insufficiency, have
lower oxygen concentrations, higher lactate concentrations, and increased hepatic glucose …
lower oxygen concentrations, higher lactate concentrations, and increased hepatic glucose …
Chronic hypoxemia in late gestation decreases cardiomyocyte number but does not change expression of hypoxia‐responsive genes
KJ Botting, IC McMillen, H Forbes… - Journal of the …, 2014 - Am Heart Assoc
Background Placental insufficiency is the leading cause of intrauterine growth restriction in
the developed world and results in chronic hypoxemia in the fetus. Oxygen is essential for …
the developed world and results in chronic hypoxemia in the fetus. Oxygen is essential for …
Reduced in utero substrate supply decreases mitochondrial abundance and alters the expression of metabolic signalling molecules in the fetal sheep heart
Babies born with fetal growth restriction (FGR) are at higher risk of develo**
cardiometabolic diseases across the life course. The reduction in substrate supply to the …
cardiometabolic diseases across the life course. The reduction in substrate supply to the …
Cardiorespiratory consequences of intrauterine growth restriction: Influence of timing, severity and duration of hypoxaemia
At birth, weight of the neonate is used as a marker of the 9-month journey as a fetus. Those
neonates born less than the 10th centile for their gestational age are at risk of being …
neonates born less than the 10th centile for their gestational age are at risk of being …
Analysis of testis metabolome and transcriptome from the oriental river prawn (Macrobrachium nipponense) in response to different temperatures and illumination …
S **, Y Hu, H Fu, S Sun, S Jiang, Y **ong… - … and Physiology Part D …, 2020 - Elsevier
A better understanding of the mechanisms underlying the male sexual differentiation of
Macrobrachium nipponense is urgently needed in order to maintain sustainable …
Macrobrachium nipponense is urgently needed in order to maintain sustainable …