Traumatic brain injury (TBI) remains one of the most fatal and debilitating conditions in the
world. Current clinical management in severe TBI patients is mainly concerned with …

Traumatic brain injury (TBI) is the most common cause of death and disability in those aged
under 40 years in the UK. Higher rates of morbidity and mortality are seen in low-income …

Severe traumatic brain injury (TBI) is currently managed in the intensive care unit with a
combined medical–surgical approach. Treatment aims to prevent additional brain damage …

Neurocritical care depends, in part, on careful patient monitoring but as yet there are little
data on what processes are the most important to monitor, how these should be monitored …

Intracranial pressure monitoring (ICP) is based on the doctrine proposed by Monroe and
Kellie centuries ago. With the advancement of technology and science, various invasive and …

Diagnostic and prognostic biomarkers for mild traumatic brain injury (TBI), also known as
concussion, remain a major unmet clinical need. Moderate to severe TBI can be diagnosed …

Complex metabolic disruption is a crucial aspect of the pathophysiology of traumatic brain
injury (TBI). Associations between this and systemic metabolism and their potential …

Microdialysis enables the chemistry of the extracellular interstitial space to be monitored.
Use of this technique in patients with acute brain injury has increased our understanding of …

This work presents the design, fabrication, and characterization of a robust 3D printed
microfluidic analysis system that integrates with FDA-approved clinical microdialysis probes …

Background Microglial polarization toward pro-inflammatory M1 phenotype are major
contributors to the development of perioperative neurocognitive disorders (PNDs). Metabolic …