Resistant hypertension (RH) is defined as above-goal elevated blood pressure (BP) in a
patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a …

The deep evolutionary history of African populations, since the emergence of modern
humans more than 300,000 years ago, has resulted in high genetic diversity and …

In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure
to identify genes, tissues, phenomes and medication contexts of blood pressure …

More than 90% of common variants associated with complex traits do not affect proteins
directly, but instead the circuits that control gene expression. This has increased the urgency …

To dissect the genetic architecture of blood pressure and assess effects on target organ
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …

Hypertension is available at http://hyper. ahajournals. org DOI: 10.1161/HYP.
0000000000000047 e8 Hypertension September 2016 distributed trait. Therefore, defining …

Advance Access Publication Date: 26 March 2019 Cohort Profile education, dietary factors
and behavioural/lifestyle factors. In addition to inherited and behavioural factors, unique …

Longitudinal electronic health records on 99,785 Genetic Epidemiology Research on Adult
Health and Aging (GERA) cohort individuals provided 1,342,814 systolic and diastolic blood …

Genome-wide association studies (GWASs) have identified many genetic variants
underlying complex traits. Many detected genetic loci harbor variants that associate with …

Meta-analyses of association results for blood pressure using exome-centric single-variant
and gene-based tests identified 31 new loci in a discovery stage among 146,562 …