[HTML][HTML] Effects of helminths on the human immune response and the microbiome

SC Lee, OO Oyesola - Mucosal Immunology, 2022 - Elsevier
Helminths have evolved sophisticated immune regulating mechanisms to prevent rejection
by their mammalian host. Our understanding of how the human immune system responds to …

Helminths' therapeutic potential to treat intestinal barrier dysfunction

TC Mules, S Inns, G Le Gros - Allergy, 2023 - Wiley Online Library
The intestinal barrier is a dynamic multi‐layered structure which can adapt to environmental
changes within the intestinal lumen. It has the complex task of allowing nutrient absorption …

Interactions between parasitic helminths and gut microbiota in wild tropical primates from intact and fragmented habitats

C Barelli, C Donati, D Albanese, B Pafčo, D Modrý… - Scientific reports, 2021 - nature.com
The mammalian gastrointestinal tract harbours a highly complex ecosystem composed of a
variety of micro-(bacteria, fungi, viruses, protozoans) and macro-organisms (helminths) …

Controlled infection with cryopreserved human hookworm induces CTLA-4 expression on Tregs and upregulates tryptophan metabolism

F Vacca, TC Mules, M Camberis, B Lavender… - Gut …, 2024 - Taylor & Francis
Infecting humans with controlled doses of helminths, such as human hookworm (termed
hookworm therapy), is proposed to prevent or treat various intestinal and extraintestinal …

Cooperation between host immunity and the gut bacteria is essential for helminth-evoked suppression of colitis

A Shute, BE Callejas, SH Li, A Wang, TS Jayme… - Microbiome, 2021 - Springer
Background Studies on the inhibition of inflammation by infection with helminth parasites
have, until recently, overlooked a key determinant of health: the gut microbiota. Infection with …

Immune profiling, microbiome, metabolomics, and gut physiology of a 1-year controlled human hookworm infection

F Vacca, B Lavender, SL Noble, A Cait, K Maclean… - MedRxiv, 2023 - medrxiv.org
The observation that experimental helminth infection can be associated with
immunomodulation and suppression of inflammatory diseases at distal tissue sites, has …

Unbalanced relationships: insights into the interaction between gut microbiota, geohelminths, and schistosomiasis

MP de Araújo, MO Sato, M Sato, KMB Wm, LFL Coelho… - PeerJ, 2022 - peerj.com
Hosts and their microbiota and parasites have co-evolved in an adaptative relationship
since ancient times. The interaction between parasites and intestinal bacteria in terms of the …

The Impact of Intestinal Inflammation on Nematode's Excretory–Secretory Proteome

M Maruszewska-Cheruiyot, L Szewczak… - International Journal of …, 2023 - mdpi.com
Parasitic nematodes and their products are promising candidates for therapeutics against
inflammatory bowel diseases (IBD). Two species of nematodes, the hookworm Necator …

Relevance of Helminth-Microbiota interplay in the host immune response

GM Corral-Ruiz, LE Sánchez-Torres - Cellular Immunology, 2022 - Elsevier
Helminths have been present throughout the evolution of humans, promoting the
development and maturation of the host immune system. However, this interaction is not …

人体蠕虫感染对肠道菌群影响的研究进展

张艺馨, 张本光 - 热带病与寄生虫学, 2022 - rdbzz.com
人体蠕虫感染对肠道菌群影响的研究进展 Page 1 热带病与寄生虫学2022年10月第20卷第5期
J Trop Dis Parasitol, Oct. 2022, Vol. 20, No. 5 基金项目:山东省医药卫生科技发展计划(202001050586);山东 …