One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …

Background The role of the human microbiome in health and disease is an emerging and
important area of research; however, there is a concern that African populations are under …

Broad testing for respiratory viruses among persons under investigation (PUIs) for SARS-
CoV-2 has been performed inconsistently, limiting our understanding of alternative viral …

New SARS-CoV-2 mutants have been continuously indentified with enhanced transmission
ever since its outbreak in early 2020. As an RNA virus, SARS-CoV-2 has a high mutation …

Objectives Human immunodeficiency virus (HIV) quasispecies diversity presents a large
barrier to the eradication of HIV. The aim of this study was to investigate intrahost HIV …

Compared with how widely HIV-1 diversity is recognized as a critical issue for vaccine
research, relatively few genetically informed vaccine solutions have been compared, in part …

Broadly neutralizing antibodies (bNAbs) have shown great promise for prevention and
treatment of HIV infection. Breadth of bNAb neutralization, measured in vitro across panels …

Clinical metagenomics enables universal pathogen detection by unbiased next-generation
sequencing. Recent advances in sequencing and bioinformatics technology have paved the …

Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by the rapid spread
of the severe acute respiratory syndrome coronavirus-2 virus, has posed an unprecedented …

As of the year 2023, there has yet to be developed an effective prophylactic vaccine against
HIV-1 infection. One likely reason for prior failures in vaccine trials is that vaccines have …